By Edgar Haber
Subject matters lined comprise: X-ray crystallography of ligands. Catalytic antibodies. Nature of the antigen. Antibody binding websites. Maturation of the immune reaction. Computational biochemistry of antibodies and T-cell receptors. Antigen-specific T-cell receptors and their reactions. Key gains * X-Ray Crystallography of Ligands * Catalytic Antibodies * Nature of the Antigen * Antibody Binding websites * Maturtion of the Immune reaction * Computational Biochemistry of Antibodies and * T-Cell Receptors * Antigen-Specific T-Cell Receptors and Their Reactions
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Extra resources for Antibodies and T-Cell Receptors,
AL. they are occupied by rapidly dissociating natural peptides that exchange readily with peptides in the extracellular medium. Nevertheless, Eq. , 2-3 hr). , 1995) (see Section V1,D). How do pepMHC complexes recognized by T cells arise? CD8+ T cells react with pepMHC-I complexes that form within the ER of a cell as newly synthesized MHC-I molecules assemble (reviewed by Monaco, 1992; Yewdell and Bennink, 1992; Germain and Margulies, 1993; Heemels and Ploegh, 1995). , 1993). , 1994) before binding to nascent MHC-I molecules, which are then exported to the cell surface as mature pepMHC complexes.
C. , 1993). Can the reaction between TCR on the T cell and pepMHC on the target cell reach a steady state within this brief interval? , 1 - l/e) of the equilibrium number of receptor. ligand complexes. By measuring the net rate of accumulation of specific TCRopepMHC complexes on intact CD8+ 2C cells, Sykulev et al. (1994a,b) found that z was -3 min for p2Ca-Ld at 25°C and -1 min for QL9*Ldat 30 HERMAN N . EISEN E T AL 37°C. The value of z varies with the pepMHC concentration, becoming longer as the ligand concentration decreases, but it cannot be longer than approximately the half-time for dissociation [the tl,z(off) value].
These crossreactions can involve peptides having no amino acids in common except the few that serve as anchors to bind to MHC protein. Ascribed to “molecular mimicry” (Oldstone, 1987), these reactions may play an important role in stimulating autoreactive T cells (those that react with a self peptide plus a self MHC protein), thereby triggering autoimmune disorders (Wucherpfennig and Strominger, 1995). Molecular mimicry implies topological similarity between ligands that are structurally very different.
Antibodies and T-Cell Receptors, by Edgar Haber